Corticosteroid myopathy.

Corticosteroid-induced myopathy and the respiratory muscles. Report of two cases.

Two women with connective tissue disease developed a characteristic steroid-induced myopathy. Reduced maximal transrespiratory pressures indicated reduced respiratory muscle strength. Gradual steroid dosage tapering resulted in prompt clinical improvement and marked increases in respiratory muscle strength, maximal inspiratory pressure increasing by 33 percent in one patient and by 70 percent i...

Acute myopathy associated with large parenteral dose of corticosteroid in myasthenia gravis.

A 13 year old Greek girl with myasthenia gravis developed widespread muscle paralysis and atrophy after large parenteral doses of corticosteroids (5.48 g methylprednisolone). An electromyogram showed myopathy, creatine kinase concentration below normal, and a muscle biopsy showed severe myopathy with selective loss of the thick filaments (myosin). Previous reports of myopathy associated with la...

[Thyrotoxic myopathy].

A variety of neuromuscular disorders has been described in adults in association with overactivity of the thyroid (Millikan and Haines, 1953; Ramsay, 1966; Engel, 1972). The most common of these disorders is a chronic myopathy, characterized by muscular atrophy and weakness involving predominantly proximal muscles (Adams and Rosman, 1971). The myopathic symptoms may precede the symptoms of thyr...

Metabolic myopathy.

RECENT years have witnessed a considerably increased interest in disorders of muscle, resulting in large measure from the advent of new investigative techniques. This has led both to the clarification of the nature of known disorders and to the definition of new syndromes. In this review, a brief survey is given of current knowledge concerning myopathic disorders arising from metabolic disturba...

Chloroquine myopathy.